Volume 5, Issue 4, December 2019, Page: 97-104
Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release
Tetiana Rudenchyk, Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Rita Rozhnova, Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Nataliia Galatenko, Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Lіudmyla Nechaeva, Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Received: Oct. 1, 2019;       Accepted: Oct. 26, 2019;       Published: Nov. 8, 2019
DOI: 10.11648/j.ajpst.20190504.11      View  95      Downloads  42
Abstract
The study of the ability to biodegradation of film materials with D-cycloserine obtained on the basis of polyurethaneurea with fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alcohol, and 1.6-hexamethylenediamine in the structure under the influence of biological medium 199 for 1, 3 and 6 months were conducted. IR spectroscopy and physical-mechanical tests of these film materials before and after incubation in biological medium 199 were investigated. According to research results, there are decrease of the tensile strength (in 1.29-2.50 times) and a relative elongation at break (in 1.15-1.91 times) after incubation in biological medium 199. It is established that under the influence of biological medium 199 there are processes of biodegradation of film materials. The introduction of D-cycloserine into the composition of polyurethaneurea contributes to their biodegradation. It allows us to conclude that biodegradation is due to release of D-cycloserine. The study of the dynamics of D-cycloserine release from the polymer matrix was conducted by spectrophotometric method. The amount of drug varies depending on the copolymer content in structure of film materials (75.00-96.71% of the total amount of the introduced drug). It has been established that the studied film materials are capable to the prolonged release of D-cycloserine. It allows using them as film coatings for medicine with different ability to release of drug depending on requirements.
Keywords
Polyurethaneurea, D-Cycloserine, N-vinylpyrrolidone Copolymer, Model Biological Medium 199, Biodegradation
To cite this article
Tetiana Rudenchyk, Rita Rozhnova, Nataliia Galatenko, Lіudmyla Nechaeva, Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release, American Journal of Polymer Science and Technology. Vol. 5, No. 4, 2019, pp. 97-104. doi: 10.11648/j.ajpst.20190504.11
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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