Bioactive Composite Material Based on Polyurethane with Isoniazid
Dmytro Kuliesh,
Nataliia Galatenko,
Rita Rozhnova,
Ludmila Nechaeva
Issue:
Volume 9, Issue 1, March 2023
Pages:
1-6
Received:
10 February 2023
Accepted:
11 April 2023
Published:
20 April 2023
Abstract: An urgent task is the development of new implantation materials with a prolonged medicinal effect for the treatment of the extrapulmonary form of tuberculosis. The purpose of this investigation was to obtain an implantation material based on mesh polyurethane with the anti-tuberculosis drug isoniazid, to study the drug release of isoniazid from the polymer, to study the biodegradation of such materials, as well as to analyze cellular reactions to their implantation in the body of experimental animals. According to the results of the study of the dynamics of the release of isoniazid from the structure of mesh polyurethane, it was shown that a little more than 44% of isoniazid was released from the polymer matrix during the 389 days of the study. At the same time, in the first 3 days, a shock dose of the anti-tuberculosis drug was released – more than 18%, which can be important for reducing the pathological process at the location of the implant. When studying the biodegradation of the obtained materials, it was established that there was a redistribution of supramolecular structures, in which the type of these structures remained unchanged, but the size of the globular particles changed. In the model environments, the organization of large, possibly hydrophobic, destruction fragments into large globular formations probably took place, which was reflected in the increase of some physical and mechanical indicators. During implantation, the polymer material was subjected to cellular resorption due to the activity of phagocytic fragments, as well as mechanical loads, which contributed to the removal of destruction products from the mass of the polymer and led to a decrease in the main physical and mechanical parameters. According to the results of the implantation test by histological methods, it was established that around the samples of polyurethane with isoniazid a rather pronounced and long-lasting (up to 1 month) reaction of the type of aseptic inflammation was observed. At the same time, the cellular composition of the connective tissue capsule indicated a fairly good tolerability of the polymer material with prolonged release of isoniazid. It is shown that the obtained bioactive composite material based on polyurethane with isoniazid can be a promising implant material for the treatment of bone and joint tuberculosis.
Abstract: An urgent task is the development of new implantation materials with a prolonged medicinal effect for the treatment of the extrapulmonary form of tuberculosis. The purpose of this investigation was to obtain an implantation material based on mesh polyurethane with the anti-tuberculosis drug isoniazid, to study the drug release of isoniazid from the...
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Biodegradation and Physical Properties of the Polymer Blends Prepared from Cashew Nut Flour and Polyethylene-Based Waste Material
Abubakar Umar Birnin-Yauri,
Aliyu Muhammad,
Hannatu Abubakar Sani,
Shehu Abdullahi,
Abdulaziz Muhammad Hassan
Issue:
Volume 9, Issue 1, March 2023
Pages:
7-13
Received:
27 March 2023
Accepted:
2 May 2023
Published:
6 June 2023
Abstract: Plastic litters arising from polyethylene-based materials such as shopping bags, water sachets, bottles, medical wastes etc., are non-biodegradable and increasingly becoming environmental problems in the major cities of Nigeria. A possible solution is to enhance their biodegradation through addition of decomposable material. In this work, polymer blends were prepared via melt-blending approach, using polyethylene (PE), Cashew nut Flour (CNF) at a different weight percent mixing formulations. Dimensional stability test conducted revealed that the 70% PE and 30% CNF provided the best results. Thereafter, gum Arabic (GA) binder was introduced into the Polymer blend at various weight percent mixing between CNF and GA while keeping the amount of PE constant at 70%. Characterizations of the PE, CNF and GA polymer blends through Biodegradation by Composting and bench-scale stimulation methods, Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM) and thermogravimetric Analysis (TGA) analytical techniques were conducted. The results revealed that the polymer blend i.e. 70%PE, 5%CNF and 25%GA presented the highest weight lost in the two biodegradation methods which are 52.9% and 57.89%. The FTIR disclosed that the composites have almost similar spectra and peaks in the same regions with little drifts. The SEM micrographs showed some arrays of broken parts, presences of some cavities and agglomeration of the matrices in the composites. However, the blend (i.e. 70%PE, 5%CNF and 25%GA) showed that the components are more evenly distributed and resulted in little agglomeration. The study revealed that polymer blends were prepared which provided promising distinct characteristics from the original materials and with faster biodegradation rate than pure PE.
Abstract: Plastic litters arising from polyethylene-based materials such as shopping bags, water sachets, bottles, medical wastes etc., are non-biodegradable and increasingly becoming environmental problems in the major cities of Nigeria. A possible solution is to enhance their biodegradation through addition of decomposable material. In this work, polymer b...
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